Combination Training in Aging Individuals Modifies Functional Connectivity and Cognition, and Is Potentially Affected by Dopamine-Related Genes
Identifieur interne : 000440 ( Main/Exploration ); précédent : 000439; suivant : 000441Combination Training in Aging Individuals Modifies Functional Connectivity and Cognition, and Is Potentially Affected by Dopamine-Related Genes
Auteurs : Valentina Pieramico [Italie] ; Roberto Esposito [Italie] ; Francesca Sensi [Italie] ; Franco Cilli [Italie] ; Dante Mantini [Italie, Belgique] ; Peter A. Mattei [Italie] ; Valerio Frazzini [Italie] ; Domenico Ciavardelli [Italie] ; Valentina Gatta [Italie] ; Antonio Ferretti [Italie] ; Gian Luca Romani [Italie] ; Stefano L. Sensi [Italie, États-Unis]Source :
- PLoS ONE ; 2012.
Abstract
Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of the aging brain. In this study, we evaluated effects of a set of structured multimodal activities (Combination Training; CT) on cognitive performances, functional connectivity, and cortical thickness of a group of healthy elderly individuals. CT lasted six months.
Neuropsychological and occupational performances were evaluated before and at the end of the training period. fMRI was used to assess effects of training on resting state network (RSN) functional connectivity using Independent Component Analysis (ICA). Effects on cortical thickness were also studied. Finally, we evaluated whether specific dopamine-related genes can affect the response to training.
Results of the study indicate that CT improves cognitive/occupational performances and reorganizes functional connectivity. Intriguingly, individuals responding to CT showed specific dopamine-related genotypes. Indeed, analysis of dopamine-related genes revealed that carriers of
Overall, our findings support the idea that exposure to a set of structured multimodal activities can be an effective strategy to counteract aging-related cognitive decline and also indicate that significant capability of functional and structural changes are maintained in the elderly.
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DOI: 10.1371/journal.pone.0043901
PubMed: 22937122
PubMed Central: 3429431
Affiliations:
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Sensi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Departments of Neurology and Pharmacology, University of California Irvine, Irvine, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Pharmacology, University of California Irvine, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22937122</idno><idno type="pmc">3429431</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429431</idno><idno type="RBID">PMC:3429431</idno><idno type="doi">10.1371/journal.pone.0043901</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000774</idno><idno type="wicri:Area/Pmc/Curation">000774</idno><idno type="wicri:Area/Pmc/Checkpoint">000292</idno><idno type="wicri:Area/Ncbi/Merge">000560</idno><idno type="wicri:Area/Ncbi/Curation">000560</idno><idno type="wicri:Area/Ncbi/Checkpoint">000560</idno><idno type="wicri:Area/Main/Merge">000439</idno><idno type="wicri:Area/Main/Curation">000440</idno><idno type="wicri:Area/Main/Exploration">000440</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Combination Training in Aging Individuals Modifies Functional Connectivity and Cognition, and Is Potentially Affected by Dopamine-Related Genes</title><author><name sortKey="Pieramico, Valentina" sort="Pieramico, Valentina" uniqKey="Pieramico V" first="Valentina" last="Pieramico">Valentina Pieramico</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Esposito, Roberto" sort="Esposito, Roberto" uniqKey="Esposito R" first="Roberto" last="Esposito">Roberto Esposito</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Sensi, Francesca" sort="Sensi, Francesca" uniqKey="Sensi F" first="Francesca" last="Sensi">Francesca Sensi</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Cilli, Franco" sort="Cilli, Franco" uniqKey="Cilli F" first="Franco" last="Cilli">Franco Cilli</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Mantini, Dante" sort="Mantini, Dante" uniqKey="Mantini D" first="Dante" last="Mantini">Dante Mantini</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Neurosciences, Laboratory for Neuro- and Psychophysiology, Catholic University of Leuven, Leuven, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurosciences, Laboratory for Neuro- and Psychophysiology, Catholic University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Mattei, Peter A" sort="Mattei, Peter A" uniqKey="Mattei P" first="Peter A." last="Mattei">Peter A. Mattei</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Frazzini, Valerio" sort="Frazzini, Valerio" uniqKey="Frazzini V" first="Valerio" last="Frazzini">Valerio Frazzini</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Ciavardelli, Domenico" sort="Ciavardelli, Domenico" uniqKey="Ciavardelli D" first="Domenico" last="Ciavardelli">Domenico Ciavardelli</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Biochemistry, School of Motor Sciences, Kore University of Enna, Enna, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry, School of Motor Sciences, Kore University of Enna, Enna</wicri:regionArea><wicri:noRegion>Enna</wicri:noRegion></affiliation></author><author><name sortKey="Gatta, Valentina" sort="Gatta, Valentina" uniqKey="Gatta V" first="Valentina" last="Gatta">Valentina Gatta</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Psychological sciences, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychological sciences, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Functional Genomics Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Functional Genomics Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Ferretti, Antonio" sort="Ferretti, Antonio" uniqKey="Ferretti A" first="Antonio" last="Ferretti">Antonio Ferretti</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Romani, Gian Luca" sort="Romani, Gian Luca" uniqKey="Romani G" first="Gian Luca" last="Romani">Gian Luca Romani</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Sensi, Stefano L" sort="Sensi, Stefano L" uniqKey="Sensi S" first="Stefano L." last="Sensi">Stefano L. Sensi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience and Imaging, University “G. d’Annunzio” Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Neurology Unit, Center of Excellence on Aging, University “G. d’Annunzio”, Chieti-Pescara, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Departments of Neurology and Pharmacology, University of California Irvine, Irvine, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Pharmacology, University of California Irvine, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="e-ISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of the aging brain. In this study, we evaluated effects of a set of structured multimodal activities (Combination Training; CT) on cognitive performances, functional connectivity, and cortical thickness of a group of healthy elderly individuals. CT lasted six months.</p></sec><sec><title>Methodology</title><p>Neuropsychological and occupational performances were evaluated before and at the end of the training period. fMRI was used to assess effects of training on resting state network (RSN) functional connectivity using Independent Component Analysis (ICA). Effects on cortical thickness were also studied. Finally, we evaluated whether specific dopamine-related genes can affect the response to training.</p></sec><sec><title>Principal Findings</title><p>Results of the study indicate that CT improves cognitive/occupational performances and reorganizes functional connectivity. Intriguingly, individuals responding to CT showed specific dopamine-related genotypes. Indeed, analysis of dopamine-related genes revealed that carriers of <italic>DRD3 ser9gly</italic> and <italic>COMT Val158Met</italic> polymorphisms had the greatest benefits from exposure to CT.</p></sec><sec><title>Conclusions and Significance</title><p>Overall, our findings support the idea that exposure to a set of structured multimodal activities can be an effective strategy to counteract aging-related cognitive decline and also indicate that significant capability of functional and structural changes are maintained in the elderly.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Erickson, Ki" uniqKey="Erickson K">KI Erickson</name></author><author><name sortKey="Voss, Mw" uniqKey="Voss M">MW Voss</name></author><author><name sortKey="Prakash, Rs" uniqKey="Prakash R">RS Prakash</name></author><author><name sortKey="Basak, C" uniqKey="Basak C">C Basak</name></author><author><name sortKey="Szabo, A" uniqKey="Szabo A">A 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uniqKey="Millan M">MJ Millan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Swart, M" uniqKey="Swart M">M Swart</name></author><author><name sortKey="Bruggeman, R" uniqKey="Bruggeman R">R Bruggeman</name></author><author><name sortKey="Lar I, F" uniqKey="Lar I F">F Larøi</name></author><author><name sortKey="Alizadeh, Bz" uniqKey="Alizadeh B">BZ Alizadeh</name></author><author><name sortKey="Kema, I" uniqKey="Kema I">I Kema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bertolino, A" uniqKey="Bertolino A">A Bertolino</name></author><author><name sortKey="Rubino, V" uniqKey="Rubino V">V Rubino</name></author><author><name sortKey="Sambataro, F" uniqKey="Sambataro F">F Sambataro</name></author><author><name sortKey="Blasi, G" uniqKey="Blasi G">G Blasi</name></author><author><name sortKey="Latorre, V" uniqKey="Latorre V">V Latorre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ursini, G" uniqKey="Ursini G">G Ursini</name></author><author><name sortKey="Bollati, V" uniqKey="Bollati V">V Bollati</name></author><author><name sortKey="Fazio, L" uniqKey="Fazio L">L Fazio</name></author><author><name sortKey="Porcelli, A" uniqKey="Porcelli A">A Porcelli</name></author><author><name sortKey="Iacovelli, L" uniqKey="Iacovelli L">L Iacovelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stokes, Pr" uniqKey="Stokes P">PR Stokes</name></author><author><name sortKey="Rhodes, Ra" uniqKey="Rhodes R">RA Rhodes</name></author><author><name sortKey="Grasby, Pm" uniqKey="Grasby P">PM Grasby</name></author><author><name sortKey="Mehta, Ma" uniqKey="Mehta M">MA Mehta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author><author><name sortKey="Ji, Y" uniqKey="Ji Y">Y Ji</name></author><author><name sortKey="Ganesan, S" uniqKey="Ganesan S">S Ganesan</name></author><author><name sortKey="Schloesser, R" uniqKey="Schloesser R">R Schloesser</name></author><author><name sortKey="Martinowich, K" uniqKey="Martinowich K">K Martinowich</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>Italie</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="Italie"><noRegion><name sortKey="Pieramico, Valentina" sort="Pieramico, Valentina" uniqKey="Pieramico V" first="Valentina" last="Pieramico">Valentina Pieramico</name></noRegion><name sortKey="Ciavardelli, Domenico" sort="Ciavardelli, Domenico" uniqKey="Ciavardelli D" first="Domenico" last="Ciavardelli">Domenico Ciavardelli</name><name sortKey="Ciavardelli, Domenico" sort="Ciavardelli, Domenico" uniqKey="Ciavardelli D" first="Domenico" last="Ciavardelli">Domenico Ciavardelli</name><name sortKey="Cilli, Franco" sort="Cilli, Franco" uniqKey="Cilli F" first="Franco" last="Cilli">Franco Cilli</name><name sortKey="Esposito, Roberto" sort="Esposito, Roberto" uniqKey="Esposito R" first="Roberto" last="Esposito">Roberto Esposito</name><name sortKey="Ferretti, Antonio" sort="Ferretti, Antonio" uniqKey="Ferretti A" first="Antonio" last="Ferretti">Antonio Ferretti</name><name sortKey="Frazzini, Valerio" sort="Frazzini, Valerio" uniqKey="Frazzini V" first="Valerio" last="Frazzini">Valerio Frazzini</name><name sortKey="Frazzini, Valerio" sort="Frazzini, Valerio" uniqKey="Frazzini V" first="Valerio" last="Frazzini">Valerio Frazzini</name><name sortKey="Gatta, Valentina" sort="Gatta, Valentina" uniqKey="Gatta V" first="Valentina" last="Gatta">Valentina Gatta</name><name sortKey="Gatta, Valentina" sort="Gatta, Valentina" uniqKey="Gatta V" first="Valentina" last="Gatta">Valentina Gatta</name><name sortKey="Mantini, Dante" sort="Mantini, Dante" uniqKey="Mantini D" first="Dante" last="Mantini">Dante Mantini</name><name sortKey="Mattei, Peter A" sort="Mattei, Peter A" uniqKey="Mattei P" first="Peter A." last="Mattei">Peter A. Mattei</name><name sortKey="Pieramico, Valentina" sort="Pieramico, Valentina" uniqKey="Pieramico V" first="Valentina" last="Pieramico">Valentina Pieramico</name><name sortKey="Romani, Gian Luca" sort="Romani, Gian Luca" uniqKey="Romani G" first="Gian Luca" last="Romani">Gian Luca Romani</name><name sortKey="Sensi, Francesca" sort="Sensi, Francesca" uniqKey="Sensi F" first="Francesca" last="Sensi">Francesca Sensi</name><name sortKey="Sensi, Stefano L" sort="Sensi, Stefano L" uniqKey="Sensi S" first="Stefano L." last="Sensi">Stefano L. Sensi</name><name sortKey="Sensi, Stefano L" sort="Sensi, Stefano L" uniqKey="Sensi S" first="Stefano L." last="Sensi">Stefano L. Sensi</name></country><country name="Belgique"><noRegion><name sortKey="Mantini, Dante" sort="Mantini, Dante" uniqKey="Mantini D" first="Dante" last="Mantini">Dante Mantini</name></noRegion></country><country name="États-Unis"><region name="Californie"><name sortKey="Sensi, Stefano L" sort="Sensi, Stefano L" uniqKey="Sensi S" first="Stefano L." last="Sensi">Stefano L. Sensi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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